City of Hope

City of Hope in Northern Illinois

Working together to bring hope to cancer patients in the midwest

Leading-Edge Cancer Care and Research Expanded to the Midwest

City of Hope® is a nationally recognized leader in the treatment of life-threatening diseases, including cancer, with over a century of pioneering research and clinical excellence. Our physicians and scientists are at the forefront of translational medicine, rapidly advancing laboratory discoveries into evidence-based therapies that redefine cancer care.

To address access and improve outcomes in the communities we serve, we expanded our footprint to offer three Northern Illinois locations that service Lake and Cook counties, as well as Southeastern Wisconsin, Northern Indiana and Michigan. Each of our locations are staffed by multidisciplinary teams with deep expertise in oncology, coordinating together under the same roof to achieve the best possible outcomes.

Our Chicago-area physicians work in close collaboration with referring providers, offering support ranging from full-spectrum oncology care to specific procedures, diagnostics and screenings. Appointments are typically available within days, and we provide a seamless logistics management for referred patients. Additionally, we prioritize continuity of care by ensuring a smooth transition back to the referring provider upon completion of treatment.

Refer a Patient to City of Hope

We strive to offer a well-coordinated experience for our referring providers. Upon receiving your referral, our team will immediately begin processing the referral, with minimal work on your end.

Please select a location City of Hope Chicago City of Hope Downtown Chicago City of Hope North Shore
Address

2520 Elisha Ave.
Zion, IL 60099

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Contact information

Phone: (847) 746-9990

Fax: (847) 342-4089

Email: [email protected]

Address

160 Upper E. Illinois St.
Chicago, IL 60611

Contact information

Phone: (847) 746-9990

Fax: (847) 342-4089

Email: [email protected]

Address

9300 Waukegan Rd.
Morton Grove, IL 60053

Contact information

Phone: (847) 675-3900

Fax: (847) 675-3930

Email: [email protected]

Primary Service Lines

Hematologic Malignancies and Stem Cell Transplant Program

The Hematologic Malignancy and Cellular Therapy Program at City of Hope Cancer Center Chicago focuses on the diagnosis and treatment of all hematologic malignancies. Our longstanding program is the only location offering the full spectrum of transplant services between Chicago and Milwaukee.

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Breast Cancer Treatments and Technologies

The City of Hope Chicago Breast Cancer Program provides multidisciplinary care to diagnose and treat all types and stages of breast cancer. Our program offers patients the specialty care they deserve from diagnosis through survivorship, with physicians who specialize in early stage, advanced stage and recurrent breast cancer.

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Gastrointestinal Cancers Treatments and Technologies

City of Hope Chicago’s Gastrointestinal (GI) Cancer Program offers diagnosis and treatment for all GI cancers. Offering a large spectrum of treatment options, including interventional gastroenterology, advanced surgical procedures, radiation therapy and hepatic artery infusion therapy, the program is structured to see patients rapidly, within a week or less from the time of referral.

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Genitourinary Cancers Treatments and Technologies

The City of Hope team diagnoses and treats all types and stages of genitourinary cancers through the Genitourinary Cancer Program. Providing innovative advancements in care, our team offers hypofractionated approaches and salvage radiation therapy for prostate cancer, as well as radiopharmaceutical treatments. Our program also places a strong focus on preserving patients’ urinary and sexual health.

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Gynecologic Cancers Treatments and Technologies

The City of Hope Chicago Gynecologic Oncology Program provides specialized, collaborative care to treat all stages of gynecologic cancers, including early stage, advanced stage and recurrent malignancies. Our program delivers personalized patient care and focuses on all aspects of survivorship. Additionally, our surgeons are experts in complex, minimally invasive and robotic-assisted surgeries.

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Lung Cancer Treatments and Technologies

The City of Hope Chicago Lung Cancer Program offers specialized, collaborative care to treat all stages and types of lung cancer. Additionally, with the incidence of indeterminate pulmonary nodules on the rise, we offer a Rapid Undiagnosed Lung Nodule program to provide expedited access to biopsies, and if necessary, a diagnosis and treatment plan in as little as one week.

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Skin Cancer Treatments and Technologies

The Skin Cancer Program at City of Hope Chicago provides specialized, collaborative care to treat all stages of skin cancer, offering advanced options such as Mohs micrographic surgery to treat malignancy while restoring appearance and preserving quality of life.

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Clinical Services and Offerings at Our Midwest Locations

At City of Hope Chicago, our clinical experts all have one collective goal: to treat cancer with precision and compassion so our patients can get back to life. We offer a comprehensive range of oncology services, including:

Because of the growing need of chemotherapy and radiation therapy for indications other than cancer, we’ve expanded our expertise with these modalities. We offer treatment for certain benign diseases, including hematology, multiple sclerosis, thyroid eye disease, gout, osteoarthritis, Dupuytren’s contracture and heterotopic ossification.

Meet Our Illinois Oncology Experts

Our physicians treat all solid and hematologic cancers, including early- and advanced-stage disease, as well as recurrent and metastatic disease. Our clinical team is backed by a national network of nearly 2,100 physicians and researchers working together so we can achieve better outcomes.

As experts in their field, many of our physicians are primary investigators for clinical trials and hold faculty positions both within City of Hope and externally.

Request a Consultation

Referring physicians can speak directly with a City of Hope physician to discuss patient care or make a referral.

Our Northern Illinois Locations

City of Hope Cancer Center, located in Lake County, Illinois, offers a comprehensive suite of technology for screening, diagnosing and treating cancer, delivered by highly specialized experts. Additionally, patients may receive the excellent care at our City of Hope outpatient care locations in the Chicagoland area.

Accepted Insurance Health Plans

Because of the complexity involved in insurance plan design, we’ve developed a quick and efficient process to verify your patient’s insurance benefits—requiring minimal effort on your end.

View the insurance plans our Chicago-area locations are in network with below.

Our History of Clinical Excellence

Our Illinois cancer center has been an accredited facility for nearly four decades by the American College of Surgeons Commission on Cancer for providing outstanding quality care to cancer patients. Additionally, we are recognized by multiple organizations for our superior clinical performance, including:

Latest Chicago Cancer News

June 17, 2026 | By City of Hope
Expanding Supportive Care to Meet the Growing Needs of Cancer Survivors
June 10, 2026 | By City of Hope
David B. Stewart, Sr., M.D., Named Chief of Surgery at City of Hope Cancer Center Chicago
May 05, 2026 | By City of Hope
Advancing Access to TIL Therapy for Metastatic Melanoma

Dedication to Speed to Care

City of Hope Cancer Center and our outpatient cancer care locations are intentionally structured to maximize speed to care, with:

Appointments available in as little as 24 hours and treatment within one week or less
Two- to four-hour radiology turnaround
48-hour pathology turnaround